PPIs prematurely age cells that line the inside of blood vessels.

“The side effects of long term Omeprazole, Nexium and its related drugs, called PPIs, is alarming. On May 10 a report described PPI drugs being associated with central nervous system dysfunction. Avoid PPI drugs and use Zantac and its class of medications.” Bill Chesnut, MD

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PPIs prematurely age cells that line the inside of blood vessels, study suggests.  AMA Wire  __May 11, 2016.

The Houston Chronicle (5/10, Hawryluk) reports that research suggests “proton pump inhibitors prematurely age the cells that line the inside of blood vessels, making them less resistant to blockages that can cause heart attacks and strokes.” The findings were published in Circulation Research.

HealthDay (5/10, Thompson) reports that the findings, from “lab tests,” may “explain why other studies have shown increased risk of heart disease in people who use” PPIs, “said study senior author Dr. John Cooke.”


CIRCULATION RESEARCH_American Heart Association.

Proton Pump Inhibitors Accelerate Endothelial Senescence

Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal and neurological morbidity.

Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI induced vascular dysfunction.

Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.

Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal and neurological morbidity and mortality.