How are Bioidentical Estradiol and Progesterone Produced? What about Compounding Pharmacies?

“Dr. Lindner has a lot of helpful information he posted at his website He has a depth of experience with menopause hormone deprivation symptoms and their treatment. This is about bioidentical hormone replacement as an example of the information he has. He writes a good explanation of the term bioidentical medications. ” Bill Chesnut, MD

Henry Lindner, MD

How are Bioidentical Estradiol and Progesterone Produced? What about Compounding Pharmacies?
“Bioidentical” is the term that signifies that the molecule is exactly the same as the one in our bodies. Yams,
soy, and other plants contain a molecule called diosgenin that has no hormonal effects, but it is similar to cholesterol and is
easily converted by chemical processes into bioidentical estradiol, progesterone, testosterone, cortisol, and DHEA.
However, all the alien steroid substitutes are also made from diosgenin. The issue is not whether the molecule is natural or
synthetic–the source does not matter–it’s the chemical structure that makes a hormone right or not. Also, the route of
delivery is very important as bioidentical estradiol can cause problems if swallowed. The body accepts and metabolizes
bioidentical hormones as if it made them. There are FDA-approved bioidentical estradiol and progesterone products, but
they are often expensive and hard to individualize. They are often not in the best form for delivery. There isn’t any FDA-
approved testosterone for women (The drug companies are trying to fix that!) Therefore many physicians prefer to
prescribe compounded estradiol, progesterone, and testosterone. A compounding pharmacy uses USP-certified
bioidentical hormones (the same raw products used in FDA-approved products). They simply combine carefully measured
amounts of the hormone powder into a delivery vehicle–a cream, gel, tablet, or capsule. Nothing could be simpler.
Pharmacists are certified experts. They take their responsibilities seriously. Any slight batch to-batch differences in
concentration or delivery that may occur are insignificant to hormone replacement. Compounded hormones work
perfectly well, are very convenient, and are less expensive in most cases. 
The scare-mongering lies about
compounded hormones that you are hearing are just drug-company propaganda passed on through drug company-
funded professional organizations
 like ACOG and NAMS straight to your local OB/GYN. (ACOG=American College of
Obstetrics and Gynecology, NAMS=North American Menopause Society)