High-dose vitamin D3 may modulate immune system in patients with MS

AMA News 12.31.15 reports that vitamin D3 taken as a supplement to patients with multiple sclerosis showed a decrease of harmful cell activity at 10,400 international units a day. This finding is important because MS touches many of us and its effects are profound. It is easy to check possible overdoing the Vit D3 with a simple blood test. You want your blood level of Vit. D3 to be < 100 ng/dl.” Bill Chesnut, MD.

High-dose vitamin D3 may modulate immune system in patients with MS

Newsweek (12/31, Main) reports that in a study published online Dec. 30 in Neurology, researchers “tested the impact of two levels of vitamin D supplementation among 80 patients” with multiple sclerosis. Half the patients “were given 10,400 international units of Vitamin D, and the other 40 took 800 IUs of the supplement per day.” Researchers found that patients “in the high-dose group had significantly reduced levels of activity among a certain type of immune cell thought to be involved in multiple sclerosis, compared with those in the low-dose group.”

According to MedPage Today (12/31, Jackson), in patients taking high-dose vitamin D3 (cholecalciferol), researchers found “in vivo pleiotropic immunomodulatory effects” as evidenced by the “significant reduction in the proportion of interleukin-17+CD4+ T cells (P=0.016), CD161+CD4+ T cells (P=0.03), and effector memory CD4+ T cells (P=0.021),” as well as “a concomitant increase in the proportion of central memory CD4+ T cells

AMA Wire newsletter January, 2016.